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Sio Capital Management, LLC

Portfolio

Holdings

Most recent quarter

% of Total Shares

% of Total Assets

Shares

Book Value

Market Price Value

Fundamental Score

ADC Therapeutics SA

2024-09-30

4.085

0.915

3.2m

-$5.4m

$6.6m

2024-09-30

0.55

0.854

821k

$895.7k

$1m

AGLE.NASDAQ

-

-

-

-

2.97

0.431

3m

-

-

Aprea Therapeutics Inc

2024-09-30

5.089

0.302

276.6k

$1m

$868.5k

2024-09-30

0.448

0.153

692.3k

$462.4k

$3.2m

Arcutis Biotherapeutics Inc

2024-09-30

0.657

1.045

635.9k

$801.3k

$9.5m

ASLN.NASDAQ

-

-

-

-

1.123

0.047

254.1k

-

-

Astria Therapeutics Inc

2024-09-30

0.895

2.204

504.8k

$3m

$4.8m

Avalo Therapeutics Inc

2024-09-30

0.683

0.269

71.4k

$139.6k

$629.5k

Bicycle Therapeutics Ltd

2024-09-30

2.112

4.956

796.9k

$9.5m

$11.7m

Diagnostics & Research

2024-09-30

2.983

3.062

4.3m

$824.3k

$6.3m

CBAY.NASDAQ

-

-

-

-

0.656

0.616

555.6k

-

-

Compass Pathways Plc

Medical Care Facilities

2024-09-30

1.337

2.285

914.6k

$2.5m

$3.6m

Centessa Pharmaceuticals PLC ADR

2024-09-30

0.775

1.516

756.8k

$2.8m

$12.7m

Connect Biopharma Holdings Ltd

2024-06-30

1.086

0.192

597.6k

$1m

$595.2k

Context Therapeutics Inc

2024-09-30

1.771

1.032

1.3m

$1.3m

$1.5m

Corbus Pharmaceuticals Holding

2024-09-30

1.87

2.757

225.1k

$2.7m

$2.9m

CytomX Therapeutics Inc

2024-09-30

2.052

1.038

1.5m

-$439.6k

$1.7m

Cyclacel Pharmaceuticals Inc

2024-09-30

3.624

0.184

454.3k

-$69.9k

$144.4k

Precision BioSciences Inc

2024-09-30

0.911

0.606

1m

$8.5m

$4.5m

Elevation Oncology Inc

2024-09-30

2.068

0.823

876.6k

$1m

$494.4k

Medical Instruments & Supplies

2024-09-30

1.015

2.313

585.4k

-$7.4m

$11.8m

2024-09-30

1.018

1.836

2.8m

$4.5m

$7.3m

Foghorn Therapeutics Inc

2024-09-30

0.219

0.449

121.6k

-$54.9k

$610.7k

FUSN.NASDAQ

-

-

-

-

0.34

0.198

246k

-

-

GRCL.NASDAQ

-

-

-

-

5.179

11.43

5m

-

-

HARP.NASDAQ

-

-

-

-

1.392

0.771

297.9k

-

-

Healthcare Services Group Inc

Medical Care Facilities

2024-09-30

1.1

1.913

810.3k

$5.3m

$9.3m

HSAQ.NASDAQ

-

-

-

-

2.23

0.923

250k

-

-

2024-09-30

1.68

1.852

2m

-$990k

$9m

2024-09-30

0.935

1.557

365.2k

$4.2m

$5.2m

Medical Devices

2024-09-30

1.248

2.09

286.6k

$2.2m

$2.4m

ISO.NASDAQ

-

-

-

-

1.033

0.33

407.1k

-

-

MACK.NASDAQ

-

-

-

-

1.985

0.881

288.4k

-

-

Moleculin Biotech Inc

2024-09-30

0.91

0.036

271.2k

$546.2k

$493.6k

Modular Medical Inc

Medical Devices

2024-09-30

0.301

0.108

120.7k

$20.7k

$159.4k

MSAC.NASDAQ

-

-

-

-

20.00

8.651

2.3m

-

-

NBSE.NASDAQ

-

-

-

-

0.784

0.032

259.4k

-

-

Nektar Therapeutics

2024-09-30

3.68

1.023

6.9m

$1.6m

$6.3m

NVCN.NASDAQ

-

-

-

-

0.81

0.325

22.5k

-

-

2024-09-30

0.464

0.071

130k

$350.8k

$112.8k

Ocular Therapeutix Inc

2024-09-30

0.654

0.987

971.4k

$2m

$8m

Orthofix Medical Inc

Medical Devices

2024-09-30

1.768

2.587

650k

$8.8m

$11.2m

Pmv Pharmaceuticals Inc

2024-09-30

6.211

1.899

3.2m

$12.2m

$4.7m

PNT.NASDAQ

-

-

-

-

0.515

1.337

544.5k

-

-

PRDS.NASDAQ

-

-

-

-

0.506

0.364

315.5k

-

-

Prelude Therapeutics Inc

2024-09-30

0.582

0.33

320.3k

$660.6k

$381.2k

Relmada Therapeutics Inc

2024-09-30

0.782

0.304

235.5k

$371.6k

$85k

Repare Therapeutics Inc

2024-09-30

0.543

1.112

228.5k

$940.6k

$308.5k

Sight Sciences Inc

Medical Devices

2024-09-30

0.506

0.257

246.6k

$464.7k

$875.7k

SIEN.NASDAQ

-

-

-

-

2.264

0.194

254.9k

-

-

Smith & Nephew SNATS Inc

Medical Devices

2024-06-30

0.133

3.887

579.6k

$6.9m

$14.1m

SOLY.NASDAQ

-

-

-

-

3.819

5.353

824.8k

-

-

Silverback Therapeutics Inc

2024-09-30

0.553

1.632

536.1k

$1.1m

$6.1m

2024-09-30

0.662

1.049

896.2k

$843.3k

$2.8m

Third Harmonic Bio Inc.

2024-09-30

0.365

0.575

163.3k

$1m

$1.6m

Tyra Biosciences Inc

2024-09-30

0.792

3.737

400.8k

$2.4m

$5.6m

Vincerx Pharma Inc

2024-09-30

0.344

0.154

102k

$20.3k

$18.9k

Viking Therapeutics Inc

2024-09-30

1.304

1.086

999.8k

$8.1m

$42.3m

VRAY.NASDAQ

-

-

-

-

3.507

0.576

6.4m

-

-

2024-09-30

0.3

0.158

133.4k

$96.5k

$520.3k

Ventyx Biosciences Inc

2024-09-30

2.789

1.705

1.9m

$7.7m

$4.4m

2024-09-30

5.982

4.582

13.6m

$4m

$8.2m

X4 Pharmaceuticals Inc

2024-09-30

0.764

0.346

1.3m

$387.1k

$756k

Trades

Buys

Report date: 2024-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
BDSX.NASDAQ	4.3m	-	6.2m	1-2	$1.46	27.0%
CMPS.NASDAQ	293.4k	-	2.3m	6-10	$4.03	-29.7%
CNTX.NASDAQ	1.3m	-	2.2m	1-2	$1.15	-6.5%
CRBP.NASDAQ	225.1k	-	9.4m	32-55	$13.17	-58.9%
PMVP.NASDAQ	2.7m	-	4.8m	1-2	$1.47	-1.3%
SNN.NYSE	579.6k	-	14.4m	24-26	$24.44	3.3%
VSTM.NASDAQ	133.4k	-	1m	3-14	$3.90	39.3%
VXRT.NASDAQ	14.7m	-	12.2m	1-1	$0.61	17.1%

Report date: 2024-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
AVTX.NASDAQ	10.1k	-	54.6k	4-34	$8.81	123.0%
CTMX.NASDAQ	1.5m	-	2.9m	1-3	$1.07	-22.5%
ERAS.NASDAQ	2.4m	-	4.8m	2-3	$2.57	56.7%
HUMA.NASDAQ	2m	-	6.7m	2-5	$4.51	81.9%
TYRA.NASDAQ	535.7k	-	8.7m	11-21	$14.09	25.4%

Report date: 2023-12-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
FHTX.NASDAQ	121.6k	-	524.8k	3-7	$5.02	76.8%
OCUL.NASDAQ	971.4k	-	2.8m	2-5	$8.33	317.5%
THRD.NASDAQ	163.3k	-	1.2m	6-12	$10.32	79.0%

Report date: 2023-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
EMBC.NASDAQ	568.2k	-	10.6m	15-24	$20.28	37.9%
GRCL.NASDAQ	2m	-	7.6m	3-5	-	-
HARP.NASDAQ	168k	-	375k	1-9	-	-
HCSG.NASDAQ	810.3k	-	10.1m	10-15	$11.51	11.2%
OFIX.NASDAQ	650k	-	11.6m	12-22	$17.34	41.5%
PRLD.NASDAQ	350k	-	1.3m	3-5	$1.19	-55.1%
SGHT.NASDAQ	246.6k	-	1.6m	3-9	$3.55	27.7%

Report date: 2023-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
NKTR.NASDAQ	6.9m	-	4.9m	1-1	$0.91	73.8%
SPRY.NASDAQ	542.5k	-	3.6m	4-10	$11.41	186.0%
VRAY.NASDAQ	6.4m	-	0.00	0-0	-	-
XFOR.NASDAQ	1.7m	-	2.9m	1-3	$0.58	-27.6%

Report date: 2023-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ADCT.NYSE	2.1m	-	7.9m	2-6	$2.03	9.7%
APRE.NASDAQ	280k	-	902.7k	0-11	$3.14	834.2%
CNTA.NASDAQ	347.8k	-	1.2m	3-4	$16.90	463.3%
CRBP.NASDAQ	150k	-	355.8k	0-9	$13.17	11,754.2%
NVCN.NASDAQ	22.5k	-	0.00	0-0	-	-
RPTX.NASDAQ	228.5k	-	2.6m	9-15	$1.35	-85.4%
SIEN.NASDAQ	254.9k	-	343.4k	0-2	-	-

Report date: 2022-12-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
HUMA.NASDAQ	49.9k	-	151.7k	2-4	$4.51	130.1%
MACK.NASDAQ	250k	-	2m	3-14	-	-
RLMD.NASDAQ	235.5k	-	2m	2-37	$0.36	-80.1%

Report date: 2022-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ARDX.NASDAQ	692.3k	-	517.2k	0-1	$4.64	846.9%
DTIL.NASDAQ	1m	-	2m	1-3	$4.50	305.4%
MODD.NASDAQ	574.3k	-	2.6m	4-5	$1.32	-65.4%
SGHT.NASDAQ	724.9k	-	6.4m	6-14	$3.55	-43.2%

Sells

Report date: 2024-06-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
ASLN.NASDAQ	-254.1k	-100.0	-0.00	0-0	-	-

Report date: 2023-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
CNTB.NASDAQ	-597.6k	-100.0	-651.8k	1-2	$1.00	31.9%

Report date: 2022-06-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
AYLA.NASDAQ	-60.2k	-100.0	-140.7k	1-4	-	-

Adds

Report date: 2024-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
CMPS.NASDAQ	621.2k	211.7	4.3m	6-9	$4.03	-31.1%
PMVP.NASDAQ	505.8k	18.7	781.4k	1-2	$1.47	5.0%
VTYX.NASDAQ	1.1m	153.2	2.7m	2-3	$2.27	26.8%

Report date: 2024-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ATXS.NASDAQ	100k	24.4	976.2k	9-14	$9.54	11.1%
AVTX.NASDAQ	61.3k	604.0	795.2k	9-22	$8.81	-1.2%
ERAS.NASDAQ	447.3k	18.4	965.2k	2-3	$2.57	47.7%
TYRA.NASDAQ	64.5k	12.0	1.1m	14-21	$14.09	-0.2%
VTYX.NASDAQ	400.9k	106.1	1.6m	2-6	$2.27	0.7%

Report date: 2024-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
MODD.NASDAQ	850k	123.3	1.5m	1-2	$1.32	22.2%

Report date: 2023-12-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
EMBC.NASDAQ	167.7k	29.5	2.7m	13-19	$20.28	59.4%
GRCL.NASDAQ	2.9m	140.3	0.00	0-0	-	-
HARP.NASDAQ	129.9k	77.3	0.00	0-0	-	-
XFOR.NASDAQ	989.4k	38.1	802k	1-1	$0.58	1.4%

Report date: 2023-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ARQT.NASDAQ	342.9k	117.0	2.9m	5-11	$14.99	188.8%
SPRY.NASDAQ	563.3k	103.8	3.6m	3-8	$11.41	347.5%
XFOR.NASDAQ	850k	48.6	1.2m	1-2	$0.58	-38.9%

Report date: 2023-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ADCT.NYSE	1.8m	86.1	4.1m	2-3	$2.03	8.0%
BCYC.NASDAQ	1.3k	0.1	30.6k	19-29	$14.69	-22.0%
CNTA.NASDAQ	529.3k	152.2	2.4m	4-7	$16.90	380.1%
MACK.NASDAQ	17.9k	6.6	223.7k	12-13	-	-
SVRA.NASDAQ	62.2k	6.6	145.6k	2-3	$3.20	96.3%

Report date: 2023-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
BCYC.NASDAQ	283.9k	41.5	7.1m	20-32	$14.69	-24.7%
ELEV.NASDAQ	516.8k	143.7	666.8k	1-3	$0.56	-22.0%
MACK.NASDAQ	22.8k	9.1	268.4k	11-13	-	-
SVRA.NASDAQ	82k	9.5	184.7k	2-3	$3.20	110.5%

Report date: 2022-12-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
MODD.NASDAQ	115k	20.0	346.5k	2-5	$1.32	-15.9%
SVRA.NASDAQ	10k	1.2	13.7k	1-2	$3.20	196.3%
XFOR.NASDAQ	407.5k	28.7	643.4k	1-2	$0.58	-10.8%

Report date: 2022-09-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
PNT.NASDAQ	40k	7.9	338.5k	6-11	-	-
XFOR.NASDAQ	1.1m	412.2	1.3m	1-2	$0.58	-32.6%

Report date: 2022-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
AFMD.NASDAQ	177.4k	27.6	612.3k	2-5	$1.24	-44.4%
AGLE.NASDAQ	3.7m	435.9	5.4m	1-3	-	-
BCYC.NASDAQ	636.2k	1,205.2	13.8m	12-50	$14.69	21.6%
CYCC.NASDAQ	31.7k	7.5	54.7k	1-3	$0.32	-68.5%
FUSN.NASDAQ	685.00	0.3	3.2k	2-8	-	-
INBX.NASDAQ	240.9k	193.9	3.6m	8-26	$14.49	88.9%
INGN.NASDAQ	125.3k	31.3	3.3m	23-36	$8.43	-62.5%
PNT.NASDAQ	126.8k	33.6	972k	5-10	-	-
SVRA.NASDAQ	140.1k	19.6	184.1k	1-2	$3.20	201.9%
TYRA.NASDAQ	41.1k	37.0	330.7k	5-12	$14.09	185.8%

Reduces

Report date: 2024-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ATXS.NASDAQ	-5.3k	-1.1	-59.8k	9-13	$9.54	7.8%
BDSX.NASDAQ	-9.3k	-0.2	-16k	1-2	$1.46	-0.8%
MODD.NASDAQ	-1.4m	-92.2	-2.5m	1-3	$1.32	4.6%
TYRA.NASDAQ	-199.4k	-33.2	-4.1m	16-25	$14.09	-9.3%
VXRT.NASDAQ	-1.1m	-7.8	-884.2k	1-1	$0.61	8.7%
XFOR.NASDAQ	-1.1m	-47.9	-832k	1-1	$0.58	9.2%

Report date: 2024-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
XFOR.NASDAQ	-1m	-30.3	-1.1m	1-2	$0.58	1.8%

Report date: 2024-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
APRE.NASDAQ	-3.3k	-1.2	-21.1k	5-9	$3.14	-32.3%
EMBC.NASDAQ	-150.5k	-20.5	-2.3m	12-20	$20.28	64.6%
SPRY.NASDAQ	-569.7k	-51.5	-4.2m	5-11	$11.41	119.8%

Report date: 2023-12-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
PRLD.NASDAQ	-29.6k	-8.5	-90.1k	2-5	$1.19	-28.3%

Report date: 2023-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ADCT.NYSE	-726.1k	-18.1	-975.2k	1-2	$2.03	198.1%
BCYC.NASDAQ	-171.7k	-17.7	-3.9m	20-28	$14.69	-25.2%
CNTA.NASDAQ	-120.3k	-13.7	-821.8k	6-9	$16.90	203.9%
MACK.NASDAQ	-2.2k	-0.8	-27.6k	12-13	-	-
MBRX.NASDAQ	-32.1k	-10.6	-17.7k	0-1	$1.82	438.9%
SVRA.NASDAQ	-114.4k	-11.3	-407.3k	3-4	$3.20	16.2%

Report date: 2023-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
MBRX.NASDAQ	-707.5k	-70.0	-503.3k	1-2	$1.82	251.4%

Report date: 2023-03-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
ASLN.NASDAQ	-2.00	0.0	-2.53	0-3	-	-
FUSN.NASDAQ	-14.4k	-5.5	-56.7k	3-5	-	-
MBRX.NASDAQ	-25.8k	-2.5	-30.2k	1-1	$1.82	104.5%

Report date: 2022-12-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
AGLE.NASDAQ	-1.6m	-35.6	-1.1m	0-2	-	-
INGN.NASDAQ	-234.6k	-45.0	-5m	19-25	$8.43	-55.8%

Report date: 2022-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
BCYC.NASDAQ	-5.5k	-0.8	-131.7k	17-30	$14.69	-11.1%
INGN.NASDAQ	-4.1k	-0.8	-114.1k	22-32	$8.43	-62.2%
NBSE.NASDAQ	-647k	-71.4	-537.4k	0-1	-	-

Report date: 2022-06-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
CBAY.NASDAQ	-6.7k	-1.2	-16.2k	2-3	-	-
MBRX.NASDAQ	-3.6k	-0.4	-5.7k	1-2	$1.82	78.4%

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