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Sphera Funds Management Ltd.

Portfolio

Holdings

Most recent quarter

% of Total Shares

% of Total Assets

Shares

Book Value

Market Price Value

Fundamental Score

ADC Therapeutics SA

2024-09-30

0.212

0.103

205k

-$336.2k

$385.4k

AGLE.NASDAQ

-

-

-

-

0.663

0.031

646.4k

-

-

ALBO.NASDAQ

-

-

-

-

2.236

2.151

463.8k

-

-

ALPN.NASDAQ

-

-

-

-

0.407

0.321

200k

-

-

2024-09-30

0.949

0.276

500k

$937.5k

$3.4m

Aprea Therapeutics Inc

2024-09-30

4.968

0.118

270k

$997.6k

$986.8k

Arbe Robotics Ltd

Software - Infrastructure

2024-09-30

0.051

0.013

43.1k

$8.7k

$161.4k

Astria Therapeutics Inc

2024-09-30

2.097

1.423

1.1m

$6.9m

$8.5m

Autolus Therapeutics Ltd

2024-09-30

0.289

0.204

500k

$896k

$1.1m

CALT.NASDAQ

-

-

-

-

0.044

0.04

11.8k

-

-

Semiconductor Equipment & Materials

2024-09-30

0.424

1.054

189.4k

$1.8m

$16.9m

C4 Therapeutics Inc

2024-09-30

1.442

0.569

705.7k

$2.4m

$2.5m

CINC.NASDAQ

-

-

-

-

1.21

1.397

529.6k

-

-

CNCE.NASDAQ

-

-

-

-

2.088

1.257

1m

-

-

Crinetics Pharmaceuticals Inc

2024-09-30

1.164

1.708

626.5k

$5.6m

$25.4m

Cyclacel Pharmaceuticals Inc

2024-09-30

1.977

0.023

250k

-$38.5k

$105k

Eledon Pharmaceuticals Inc

2024-09-30

2.172

0.514

1.2m

$1.6m

$5.2m

Elevation Oncology Inc

2024-09-30

1.826

0.103

1m

$1.2m

$701.8k

Eliem Therapeutics Inc

2024-06-30

0.271

0.147

181.9k

$292k

$562.2k

2024-09-30

1.416

0.529

658.7k

$2.1m

$4.2m

FRLN.NASDAQ

-

-

-

-

0.375

0.017

16.4k

-

-

FUSN.NASDAQ

-

-

-

-

0.528

1.345

449k

-

-

Monte Rosa Therapeutics Inc

2024-09-30

0.611

0.191

375k

$939.3k

$2.1m

GRCL.NASDAQ

-

-

-

-

0.521

0.813

502.9k

-

-

Werewolf Therapeutics Inc

2024-09-30

1.407

0.212

626.8k

$1.2m

$864.9k

2024-09-30

0.593

1.309

721.1k

$2.3m

$4.6m

INFI.NASDAQ

-

-

-

-

1.626

0.049

1.4m

-

-

Inozyme Pharma Inc

2024-09-30

1.854

0.991

1.1m

$1.5m

$2.3m

Jasper Therapeutics Inc

2024-09-30

3.007

1.406

454.2k

$2.5m

$3.2m

Kiniksa Pharmaceuticals Ltd

Drug Manufacturers - Specialty & Generic

2024-09-30

0.642

0.81

450.2k

$2.7m

$8.9m

Keros Therapeutics Inc

2024-09-30

0.751

1.08

206.8k

$2.7m

$3m

Kezar Life Sciences Inc

2024-09-30

28.12

0.168

2m

$3.7m

$13.3m

LAVA Therapeutics NV

2024-09-30

0.557

0.039

146.4k

$184.3k

$142.9k

2024-09-30

0.516

0.08

48.9k

$155.4k

$818.9k

Magic Software Enterprises Ltd

Information Technology Services

2024-09-30

0.166

0.176

81.2k

$504.2k

$930.8k

2024-09-30

0.677

1.036

336.9k

$3.4m

$14.7m

ONCR.NASDAQ

-

-

-

-

2.07

0.031

540.2k

-

-

ONCR.PINK

-

-

-

-

2.07

0.031

540.2k

-

-

OUTLOOK THERAPEUTICS INC

2024-06-30

1.748

0.351

413.5k

-$252.2k

$980.1k

OTMO.NASDAQ

-

-

-

-

0.276

0.031

391.8k

-

-

Communication Services

Internet Content & Information

2024-09-30

0.496

0.294

234.6k

$3.5m

$2m

PNT.NASDAQ

-

-

-

-

0.894

1.157

952.6k

-

-

Praxis Precision Medicines Inc

2024-09-30

2.443

1.511

4.8m

$98.2m

$306.2m

Poseida Therapeutics Inc

2024-09-30

0.349

0.147

300k

$266.4k

$2.8m

Rigel Pharmaceuticals Inc

2024-09-30

0.7

0.287

1.2m

-$1m

$19.9m

Relmada Therapeutics Inc

2024-09-30

1.632

0.948

466.8k

$736.6k

$192.3k

Cartesian Therapeutics Inc.

2024-09-30

0.105

0.092

25k

$777.17

$422.1k

2024-09-30

2.066

0.924

1.1m

$1.9m

$5.8m

SELB.NASDAQ

-

-

-

-

0.465

0.145

752.1k

-

-

Syndax Pharmaceuticals Inc

2024-09-30

1.212

3.17

1m

$4.4m

$13.5m

SpringWorks Therapeutics Inc

2024-09-30

0.86

1.413

536.6k

$3.8m

$23m

Tenax Therapeutics Inc

2024-09-30

0.856

0.016

29.1k

$133.9k

$181.9k

Vigil Neuroscience Inc

2024-09-30

4.03

0.892

1.6m

$3.5m

$2.9m

VistaGen Therapeutics Inc

2024-09-30

2.904

0.387

808.5k

$2.4m

$2.4m

Ventyx Biosciences Inc

2024-09-30

1.432

0.351

1m

$3.9m

$2.1m

Trades

Buys

Report date: 2024-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
TENX.NASDAQ	29.1k	-	105.6k	3-5	$6.24	122.9%

Report date: 2024-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ADCT.NYSE	685.5k	-	2.7m	2-5	$1.88	-23.3%
ELDN.NASDAQ	1.2m	-	3m	2-3	$4.04	165.8%
ELYM.NASDAQ	215.1k	-	1.4m	3-12	$3.09	22.6%
GLUE.NASDAQ	375k	-	1.9m	3-8	$5.70	77.6%
PERI.NASDAQ	234.6k	-	2.8m	8-23	$8.60	5.7%
RNAC.NASDAQ	25k	-	574.3k	0-42	$16.84	3,474.6%

Report date: 2024-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
APRE.NASDAQ	270k	-	1.6m	5-9	$3.66	-21.2%
JSPR.NASDAQ	505.2k	-	8.8m	1-31	$7.05	999.8%
LVTX.NASDAQ	367.5k	-	808.8k	1-6	$0.98	-34.5%
OTLK.NASDAQ	571.4k	-	1m	0-13	$2.37	713.9%

Report date: 2023-12-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ARBE.NASDAQ	43.1k	-	87.3k	2-2	$3.74	118.1%
FRLN.NASDAQ	16.4k	-	0.00	0-0	-	-
VIGL.NASDAQ	535.1k	-	2.7m	3-9	$1.79	-37.2%

Report date: 2023-09-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
CALT.NASDAQ	11.8k	-	204.9k	15-20	-	-
VTGN.NASDAQ	100k	-	439.9k	2-25	$2.97	82.2%

Report date: 2023-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ELEV.NASDAQ	900k	-	2.3m	1-6	$0.65	-50.4%
PRAX.NASDAQ	8.7m	-	8.8m	1-1	$63.15	7,893.7%

Report date: 2023-03-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
FUSN.NASDAQ	1.2m	-	5m	3-5	-	-
GRCL.NASDAQ	2.3m	-	4.9m	2-3	-	-
JSPR.NASDAQ	4m	-	7.4m	1-4	$7.05	414.6%
SELB.NASDAQ	2.3m	-	3.6m	1-2	-	-

Report date: 2022-12-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
AGLE.NASDAQ	440.8k	-	316.8k	0-2	-	-
ATXS.NASDAQ	469.3k	-	4.8m	7-15	$7.45	1.2%
AUTL.NASDAQ	500k	-	1.2m	2-4	$2.36	47.5%
CAMT.NASDAQ	110k	-	2.5m	21-26	$89.52	329.8%
KNSA.NASDAQ	307.2k	-	4.4m	11-17	$19.93	77.9%

Report date: 2022-09-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
ALBO.NASDAQ	359k	-	7.4m	16-27	-	-
ALPN.NASDAQ	200k	-	1.6m	7-10	-	-
CYCC.NASDAQ	250k	-	351.5k	1-2	$0.42	-58.4%
INFI.NASDAQ	1.4m	-	1.5m	1-2	-	-
MDWD.NASDAQ	688.7k	-	1.2m	1-2	$16.72	1,176.3%
PERI.NASDAQ	405.1k	-	8.1m	18-23	$8.60	-50.9%
PNT.NASDAQ	1m	-	8.9m	6-11	-	-
PSTX.NASDAQ	300k	-	988.7k	2-6	$9.50	307.7%

Report date: 2022-06-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
CNCE.NASDAQ	679.4k	-	2.6m	3-7	-	-
ETNB.NASDAQ	450k	-	1.3m	2-4	$6.51	225.5%
INZY.NASDAQ	1.1m	-	5m	3-6	$2.00	-36.7%
RIGL.NASDAQ	2.5m	-	5.1m	1-3	$16.25	2,439.1%
RZLT.NASDAQ	1.1m	-	3.8m	3-4	$4.90	92.9%

Sells

Report date: 2023-12-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
CALT.NASDAQ	-11.8k	-100.0	-222.1k	15-29	-	-

Report date: 2022-06-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
AYLA.NASDAQ	-250k	-100.0	-584.3k	1-4	-	-

Report date: 2022-03-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
MOLN.NASDAQ	-80.5k	-100.0	-1.9m	16-32	-	-

Adds

Report date: 2024-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ELDN.NASDAQ	300.00	0.0	803.46	2-3	$4.04	75.7%
ELEV.NASDAQ	749.7k	227.2	1.1m	1-3	$0.65	30.0%
SNDX.NASDAQ	212.7k	25.9	4.3m	17-25	$13.11	-24.4%

Report date: 2024-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
IMTX.NASDAQ	65k	9.8	732.4k	10-14	$6.43	-33.5%
INZY.NASDAQ	89.8k	6.5	435.4k	4-8	$2.00	-52.3%
RZLT.NASDAQ	711.2k	71.4	2.4m	2-6	$4.90	120.7%
VTYX.NASDAQ	20k	2.0	83k	2-6	$2.08	-7.8%

Report date: 2024-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
VIGL.NASDAQ	1.1m	223.4	3.7m	3-4	$1.79	-29.2%
VTYX.NASDAQ	812.7k	451.5	3.7m	2-11	$2.08	11.5%

Report date: 2023-12-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ATXS.NASDAQ	570.5k	98.3	3.1m	4-8	$7.45	74.9%
INZY.NASDAQ	328k	26.6	1.1m	3-5	$2.00	-25.8%
VTGN.NASDAQ	708.5k	708.6	2.6m	2-5	$2.97	21.2%

Report date: 2023-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ATXS.NASDAQ	109.5k	23.3	934k	7-10	$7.45	10.7%
FUSN.NASDAQ	25k	1.9	80.7k	2-5	-	-
GRCL.NASDAQ	302.8k	24.6	1.1m	3-5	-	-
INZY.NASDAQ	102.9k	9.1	524.4k	4-7	$2.00	-49.4%
JSPR.NASDAQ	1.4m	33.1	1.7m	1-2	$7.05	1,028.0%
KZR.NASDAQ	63.4k	3.2	113.1k	1-3	$6.51	502.8%

Report date: 2023-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ALT.NASDAQ	200k	66.7	896.2k	3-6	$6.87	106.9%
ATXS.NASDAQ	50k	11.9	579.1k	8-14	$7.45	-7.8%
FUSN.NASDAQ	45.7k	3.6	196.9k	3-6	-	-
JSPR.NASDAQ	230k	5.7	344.2k	1-2	$7.05	518.4%
KZR.NASDAQ	100k	5.3	262k	2-3	$6.51	190.0%

Report date: 2023-03-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
AGLE.NASDAQ	205.6k	46.6	90.2k	0-1	-	-
CAMT.NASDAQ	129.4k	117.7	3.4m	22-29	$89.52	313.9%
INZY.NASDAQ	156.8k	9.6	414.2k	1-6	$2.00	79.7%
KNSA.NASDAQ	143k	46.5	1.8m	10-16	$19.93	91.8%
KZR.NASDAQ	583k	44.7	3.3m	3-7	$6.51	110.7%
MDWD.NASDAQ	35.7k	47.4	450.4k	10-15	$16.72	62.3%
MRUS.NASDAQ	20k	6.3	348.4k	14-21	$43.85	211.4%

Report date: 2022-12-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
ALBO.NASDAQ	104.8k	29.2	0.00	0-0	-	-
CINC.NASDAQ	410.6k	345.3	0.00	0-0	-	-
CNCE.NASDAQ	50k	5.2	0.00	0-0	-	-
INZY.NASDAQ	450k	38.3	786.3k	1-3	$2.00	101.3%
KZR.NASDAQ	59.3k	4.8	440.3k	6-9	$6.51	2.5%
MRUS.NASDAQ	3.6k	1.2	64.5k	12-24	$43.85	264.5%
RIGL.NASDAQ	116.2k	5.4	106.5k	1-2	$16.25	2,333.0%

Report date: 2022-09-30

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
CNCE.NASDAQ	273.3k	40.2	1.6m	4-7	-	-
CRNX.NASDAQ	39.7k	6.8	809.1k	17-23	$40.59	132.1%
ETNB.NASDAQ	208.7k	46.4	913.5k	3-8	$6.51	117.0%
HOWL.NASDAQ	29.8k	5.0	161.2k	4-8	$1.38	-64.4%
IMTX.NASDAQ	64.6k	8.9	695.9k	8-14	$6.43	-18.6%
INZY.NASDAQ	9.4k	0.8	34.3k	2-6	$2.00	-13.3%
KROS.NASDAQ	138.8k	204.2	4.7m	26-42	$14.56	-44.2%
KZR.NASDAQ	946.1k	315.7	9.1m	8-11	$6.51	-13.9%

Report date: 2022-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ALT.NASDAQ	85.9k	6.6	529.6k	4-12	$6.87	79.4%
CCCC.NASDAQ	343.2k	94.7	3.1m	5-27	$3.67	-24.3%
CRNX.NASDAQ	64.8k	12.4	1.2m	16-28	$40.59	155.1%
HOWL.NASDAQ	12.8k	2.2	58.2k	3-8	$1.38	-59.6%
IMTX.NASDAQ	108.7k	17.5	861.2k	6-10	$6.43	11.8%
MRUS.NASDAQ	20.00	0.0	421.04	13-30	$43.85	225.7%
RLMD.NASDAQ	175.5k	60.3	3.8m	16-31	$0.41	-97.4%
SWTX.NASDAQ	76.6k	16.7	2.8m	14-64	$43.00	216.2%

Reduces

Report date: 2024-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ADCT.NYSE	-480.5k	-70.1	-1.5m	3-4	$1.88	-25.7%
ELYM.NASDAQ	-33.2k	-15.4	-234.9k	5-9	$3.09	-35.0%
IMTX.NASDAQ	-10k	-1.4	-118.3k	11-13	$6.43	-40.6%
INZY.NASDAQ	-271.5k	-18.6	-1.4m	4-6	$2.00	-52.6%
LVTX.NASDAQ	-221.1k	-60.2	-404.6k	2-2	$0.98	-36.2%
OTLK.NASDAQ	-157.8k	-27.6	-1.1m	5-9	$2.37	-54.6%
RZLT.NASDAQ	-511k	-29.9	-2.3m	4-5	$4.90	23.1%
VIGL.NASDAQ	-44.5k	-2.6	-165k	3-5	$1.79	-37.8%

Report date: 2024-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
JSPR.NASDAQ	-51k	-10.1	-1.2m	19-31	$7.05	-63.1%
OTLK.NASDAQ	-1.00	-	-8.03	7-13	$2.37	-64.4%
VIGL.NASDAQ	-38.2k	-2.2	-130.8k	2-6	$1.79	-27.5%

Report date: 2024-03-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
FUSN.NASDAQ	-636.5k	-58.6	-7.6m	8-21	-	-
INZY.NASDAQ	-190k	-12.2	-1m	4-8	$2.00	-50.5%

Report date: 2023-12-31

Trade					Current
Symbol	Shares	%	Total	Price Range	Price	%
FUSN.NASDAQ	-268.6k	-19.8	-1.3m	2-10	-	-
GRCL.NASDAQ	-1m	-67.2	-0.00	0-0	-	-
MDWD.NASDAQ	-59.5k	-54.9	-534.6k	7-11	$16.72	124.4%

Report date: 2023-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
MDWD.NASDAQ	-2.5k	-2.3	-23.8k	7-11	$16.72	135.5%
PRAX.NASDAQ	-3.9m	-44.7	-4.9m	1-2	$63.15	7,329.4%
RNAC.NASDAQ	-1.2m	-63.1	-2.8m	2-3	$16.84	733.7%
RZLT.NASDAQ	-159.1k	-13.8	-260.3k	1-2	$4.90	276.9%
SELB.NASDAQ	-1.2m	-63.1	-1.4m	1-1	-	-

Report date: 2023-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
CAMT.NASDAQ	-50k	-20.9	-1.4m	25-37	$89.52	260.9%
GRCL.NASDAQ	-1.1m	-48.0	-3.1m	1-7	-	-
IMTX.NASDAQ	-163.6k	-21.0	-1.5m	6-13	$6.43	9.0%
INZY.NASDAQ	-649.8k	-36.5	-3.8m	5-7	$2.00	-55.8%
RIGL.NASDAQ	-650.7k	-34.6	-879.2k	1-2	$16.25	1,377.3%
SELB.NASDAQ	-286.5k	-12.3	-343.3k	1-1	-	-

Report date: 2023-03-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
ATXS.NASDAQ	-48.3k	-10.3	-653.3k	11-16	$7.45	-29.7%
RIGL.NASDAQ	-400k	-17.6	-635.4k	1-2	$16.25	1,265.5%

Report date: 2022-12-31

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
IMTX.NASDAQ	-14.5k	-1.8	-150.5k	8-12	$6.43	-17.4%
MDWD.NASDAQ	-22.9k	-23.3	-63.1k	1-14	$16.72	1,353.9%
PNT.NASDAQ	-100.2k	-9.5	-743.5k	6-10	-	-

Report date: 2022-09-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
RIGL.NASDAQ	-362.4k	-14.4	-488.9k	1-2	$16.25	1,540.1%

Report date: 2022-06-30

Trade					Current
Symbol	Shares	%	Total	$ Range	Price	%
SNDX.NASDAQ	-138k	-10.8	-2.3m	13-20	$13.11	-1.2%
VTGN.NASDAQ	-1.6m	-33.5	-1.9m	1-2	$2.97	245.3%

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